Dr. Paddison received his Ph.D. from the Watson School of Biological Science at Cold Spring Harbor Laboratory. His thesis work in Dr. Greg Hannon’s lab involved co-opting the RNAi pathway for programmable post-transcriptional gene silencing in mammals, which included development of shRNAs, shRNA vectors, shRNA libraries, and pooled shRNA screening techniques. After graduate school, he accepted a prestigious Cold Spring Harbor Research Fellowship, during which he began applying functional genetic technologies in multiple stem cell systems to identify gene products affecting stem cell self-renewal, differentiation, proliferation, or survival. Since joining Fred Hutchinson Cancer Research Center, Dr. Paddison’s cancer-related work has focused on developing patient-derived Glioblastoma stem-like cells (GSCs) as a functional genetic system and experimental model of cancer. Dr. Paddison has received numerous awards and scholarships for his work, including: the American Cancer Society Research Scholar Award, an Arnold and Mabel Beckman Scholarship, the Kavli Frontiers of Science Scholar Award, the Pew Scholar Award in Biomedical Sciences, and the National Institute of Health’s Ruth L. Kirschstein National Research Service Award.